Synthetic Epigenetics To Engineer Regulation

Synthetic biology approaches to engineer T cells.

There is rapidly growing interest in learning how to engineer immune cells, such as T lymphocytes, because of the potential of these engineered cells to be used for therapeutic applications such as the recognition and killing of cancer cells. At the same time, our knowhow and capability to logically engineer cellular behavior is growing rapidly with the development of synthetic biology. Here we...

Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis.

Bottromycins represent a promising class of antibiotics binding to the therapeutically unexploited A-site of the bacterial ribosome. By inhibiting translation they are active against clinically important pathogens, such as vancomycin-resistant Enterococci. Structurally, bottromycins are heavily modified peptides exhibiting various unusual biosynthetic features. To set the stage for compound mod...

Epigenetics knocks on synthetic biology's door

Epigenetics is the study of heritable changes in gene expression without concomitant changes in DNA sequence. Due to its relevance in development, differentiation and human health, epigenetics has recently become an emerging area of science with regard to eukaryotic organisms and has shown enormous potential in synthetic biology. However, significant examples of epigenetic regulation in bacteri...

Epigenetics: Regulation of Gene Expression

Livestock genetics is currently navigating through a genomic era promoted by advances in DNA technologies. There is however a promising field that has not yet been tackled in livestock breeding and genetics: Epigenetics. Epigenetics is the study of heritable changes in gene expression and other genomic functions without altering the underlying “DNA” sequence. Epigenetics introduces a level of g...

Leveraging synthetic biology for tissue engineer- ing applications